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Sporadic inclusion body myositis(s-IBM)is characterized by late onset of slowly progressive weakness that involves the quadriceps and volar forearm muscles early in the course of the disease.There are hereditary forms of inclusion body myopathy(h-IBM)that histologically resemble s-IBM.The lack of inflammation on biopsy and the different ages at onset and patterns of muscle weakness distinguish s-IBM from h-IBM.We report twin brothers with the typical clinical and histologic features of s-IBM.The occurrence of s- IBM in these twins suggests the possibility of a genetic susceptibility to developing s-IBM. |
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